Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Neurotrophic growth factors were originally characterized for their support in neuronal
differentiation, outgrowth, and survival during development. However, it has been …

Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive
stimuli. Anxiety and mood disorders have been previously associated with dysregulation of …

Alcohol use disorder (AUD) is a multifaceted neuropsychiatric disease that combines
behavioral, psychosocial, and neurobiological aspects. Over the previous decade, animal …

Relapse, a critical issue in alcohol addiction, can be attenuated by disruption of alcohol-
associated memories. Memories are thought to temporarily destabilize upon retrieval during …

In recent years, research has identified the molecular and neural substrates underlying the
transition of moderate “social” consumption of alcohol to the characteristic alcohol use …

Excessive alcohol intake leads to mesostriatal neuroadaptations, and to addiction
phenotypes. We recently found in rodents that alcohol increases fibroblast growth factor 2 …

Alcohol use disorder is one of the most disabling diseases worldwide. Glial-cell derived
neurotrophic factor (Gdnf) shows promising results concerning the inhibition of alcohol …

Repeated alcohol intake leads to mesostriatal neuroadaptations, resulting in drinking
escalation and addiction phenotypes. Fibroblast growth factor 2 (FGF2) has been shown to …

Glial cell line‐derived neurotrophic factor (GDNF) has been extensively studied for its role in
the development and maintenance of the midbrain dopaminergic system, although evidence …