The neoplastic stromal cells of giant cell tumor of bone (GCTB) carry a mutation in H3F3A,
leading to a mutant histone variant, H3. 3-G34W, as a sole recurrent genetic alteration. We …

DNA topoisomerase 1 (TOP1) inhibitors are mainstays of anticancer therapy. These drugs
trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of …

The chromatin-based rule governing the selection and activation of replication origins
remains to be elucidated. It is believed that DNA replication initiates from open chromatin …

During each cell cycle, the process of DNA replication timing is tightly regulated to ensure
the accurate duplication of the genome. The extent and significance of alterations in this …

Eukaryotes use a temporally regulated process, known as the replication timing program, to
ensure that their genomes are fully and accurately duplicated during S phase. Replication …

Hepatitis B virus (HBV) integration into the host cell genome occurs early on in infection and
reportedly induces pro-oncogenic changes in hepatocytes that drive HCC initiation …

All plants and animals must replicate their DNA, using a regulated process to ensure that
their genomes are completely and accurately replicated. DNA replication timing programs …

Pancreatic carcinoma lacks effective therapeutic strategies resulting in poor prognosis.
Transcriptional dysregulation due to alterations in KRAS and MYC affects initiation …

Despite much recent progress, our understanding of the principles of plant genome
organization and its dynamics in three-dimensional space of interphase nuclei remains …

Plant cells undergo two types of cell cycles–the mitotic cycle in which DNA replication is
coupled to mitosis, and the endocycle in which DNA replication occurs in the absence of cell …