Key Clinical Points Acute High-Altitude Illnesses Acute high-altitude illnesses occur in
persons who are not acclimatized during the first days at an altitude of 2500 m or higher …

Exposure to high altitudes generates a decrease in the partial pressure of oxygen, triggering
a hypobaric hypoxic condition. This condition produces pathophysiologic alterations in an …

Oxygen deprivation can be detrimental. However, chronic hypoxia is also associated with
decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude …

Characterizing the effect of oxygen (O2) modulation on the brain may provide a better
understanding of several clinically relevant problems, including acute mountain sickness …

Ortiz-Prado, Esteban, Raul Patricio Fernandez Naranjo, Eduardo Vasconez, Katherine
Simbaña-Rivera, Trigomar Correa-Sancho, Alex Lister, Manuel Calvopiña, and Ginés …

Objectives To assess the efficacy of three different daily doses of acetazolamide in the
prevention of acute mountain sickness and to determine the lowest effective dose. Design …

Patients with heart failure are at a higher risk of cardiovascular events compared with the
general population, particularly during domestic or international travel. Patients with heart …

Background Acetazolamide has been reported to be effective in the prevention of acute
mountain sickness (AMS). Our aim was to conduct a systematic review of randomized …

Rapid ascent to high altitude commonly results in acute mountain sickness, and on occasion
potentially fatal high-altitude cerebral edema. The exact pathophysiological mechanisms …

Aims We assessed the haemodynamic changes induced by exposure to high altitude
hypoxia and the effects on them of acetazolamide, a drug prescribed to prevent and treat …