Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent
mental illnesses that affect the lives of millions of individuals. Although these disorders have …

Despite decades of research, the pathophysiology of bipolar disorder (BD) is still not well
understood. Structural brain differences have been associated with BD, but results from …

Considerable uncertainty exists about the defining brain changes associated with bipolar
disorder (BD). Understanding and quantifying the sources of uncertainty can help generate …

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the
pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies …

Lithium is a well-established therapeutic option for the acute and long-term management of
bipolar disorder and major depression. More recently, based on findings from translational …

Background Dementia is the leading cause of death in elderly Western populations.
Preventative interventions that could delay dementia onset even modestly would provide a …

Hafeman DM, Chang KD, Garrett AS, Sanders EM, Phillips ML. Effects of medication on
neuroimaging findings in bipolar disorder: an updated review. Bipolar Disord 2012: 14: 375 …

Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins,
lipids and damaged organelles to the lysosomes for degradation and elimination. The …

Longitudinal studies of biological domains in bipolar disorder (BD) are crucial in determining
if such baseline changes are progressive. We reviewed reported studies of longitudinal …

Objective To evaluate whether accelerated brain aging occurs in individuals with mood or
psychotic disorders. Methods A systematic review following PRISMA guidelines was …