Unraveling female reproductive senescence to enhance healthy longevity

L Dong, DBL Teh, BK Kennedy, Z Huang - Cell Research, 2023 - nature.com
In a society where women often want successful careers and equal opportunities to men, the
early nature of ovarian aging often forces women to make difficult life choices between …

Role of androgens in normal and pathological ovarian function

KA Walters - Reproduction, 2015 - rep.bioscientifica.com
Androgens mediate their actions via the androgen receptor (AR), a member of the nuclear
receptor superfamily. AR-mediated androgen action is essential in male reproductive …

Premature ovarian insufficiency: pathogenesis and therapeutic potential of mesenchymal stem cell

A Takahashi, A Yousif, L Hong, II Chefetz - Journal of Molecular Medicine, 2021 - Springer
Primary ovarian insufficiency (POI) is defined as a reduction in ovarian function before the
expected age of menopause. POI is known to increase the risk of cardiovascular disorders …

Role of androgens in the ovary

KA Walters, DJ Handelsman - Molecular and cellular endocrinology, 2018 - Elsevier
It has been well established for decades that androgens, namely testosterone (T) plays an
important role in female reproductive physiology as the precursor for oestradiol (E 2) …

Androgens and ovarian function: translation from basic discovery research to clinical impact

KA Walters, VR Paris, A Aflatounian… - Journal of …, 2019 - joe.bioscientifica.com
In the last decade it has been revealed that androgens play a direct and important role in
regulating female reproductive function. Androgens mediate their actions via the androgen …

[HTML][HTML] Can ovarian aging be delayed by pharmacological strategies?

J Zhang, Q Chen, D Du, T Wu, J Wen, M Wu… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Aging has been regarded as a treatable condition, and delaying aging could prevent some
diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as …

[HTML][HTML] Current animal model systems for ovarian aging research

H Lu, L Ma, Y Zhang, Y Feng, J Zhang… - Aging and Disease, 2022 - ncbi.nlm.nih.gov
Ovarian aging leads to menopause, loss of fertility and other disorders in multiple organs,
which brings great distress to women. For ethical reasons, it is impossible to use humans as …

[HTML][HTML] Presence of anti-Müllerian hormone (AMH) during follicular development in the porcine ovary

FRCL Almeida, NGJ Costermans, NM Soede… - PLoS …, 2018 - journals.plos.org
Background Anti-Müllerian hormone (AMH) is expressed by granulosa cells of developing
follicles and plays an inhibiting role in the cyclic process of follicular recruitment by …

Androgens and diminished ovarian reserve: the long road from basic science to clinical implementation. A comprehensive and systematic review with meta-analysis

AR Neves, P Montoya-Botero, NP Polyzos - American journal of obstetrics …, 2022 - Elsevier
Objective This study aimed to present a narrative review regarding androgen production,
androgens' role in folliculogenesis, and the available therapeutic approaches for androgen …

Dehydroepiandrosterone treatment in women with poor ovarian response undergoing IVF or ICSI: a systematic review and meta-analysis

M Zhang, W Niu, Y Wang, J Xu, X Bao, L Wang… - Journal of assisted …, 2016 - Springer
Purpose We reviewed the influence of dehydroepiandrosterone (DHEA) supplementation in
patients with poor ovarian response (POR) undergoing in vitro fertilization or …