Blebs—formation, regulation, positioning, and role in amoeboid cell migration

J Schick, E Raz - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
In the context of development, tissue homeostasis, immune surveillance, and pathological
conditions such as cancer metastasis and inflammation, migrating amoeboid cells …

Phosphatidylinositol Kinases and Phosphatases in Entamoeba histolytica

K Nakada-Tsukui, N Watanabe, T Maehama… - Frontiers in cellular …, 2019 - frontiersin.org
Phosphatidylinositol (PtdIns) metabolism is indispensable in eukaryotes. Phosphoinositides
(PIs) are phosphorylated derivatives of PtdIns and consist of seven species generated by …

Trogocytosis in unicellular eukaryotes

K Nakada-Tsukui, T Nozaki - Cells, 2021 - mdpi.com
Trogocytosis is a mode of internalization of a part of a live cell by nibbling and is
mechanistically distinct from phagocytosis, which implies internalization of a whole cell or a …

Rab7D small GTPase is involved in phago‐, trogocytosis and cytoskeletal reorganization in the enteric protozoan Entamoeba histolytica

Y Saito‐Nakano, R Wahyuni… - Cellular …, 2021 - Wiley Online Library
Rab small GTPases regulate membrane traffic between distinct cellular compartments of all
eukaryotes in a tempo‐spatially specific fashion. Rab small GTPases are also involved in …

BioFlow: a non-invasive, image-based method to measure speed, pressure and forces inside living cells

A Boquet-Pujadas, T Lecomte, M Manich, R Thibeaux… - Scientific reports, 2017 - nature.com
Cell motility is governed by a complex molecular machinery that converts physico-chemical
cues into whole-cell movement. Understanding the underlying biophysical mechanisms …

EhRho1 regulates phagocytosis by modulating actin dynamics through EhFormin1 and EhProfilin1 in Entamoeba histolytica

R Bharadwaj, S Sharma, Janhawi, R Arya… - Cellular …, 2018 - Wiley Online Library
The protist parasite Entamoeba histolytica causes amoebiasis, a major public health
problem in developing countries and a major cause of morbidity and mortality. Invasive …

Coordinated activity of amoebic formin and profilin are essential for phagocytosis

R Bharadwaj, A Bhattacharya… - Molecular …, 2021 - Wiley Online Library
For the protist parasite Entamoeba histolytica, endocytic processes, such as phagocytosis,
are essential for its survival in the human gut. The actin cytoskeleton is involved in the …

Crosstalk between Entamoeba histolytica and the human intestinal tract during amoebiasis

E Labruyère, R Thibeaux, JC Olivo-Marin, N Guillén - Parasitology, 2019 - cambridge.org
The protozoan parasite Entamoeba histolytica is the microbial agent of amoebiasis–an
infection that is endemic worldwide and is associated with high morbidity and mortality rates …

EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica

S Agarwal, G Anand, S Sharma, P Parimita Rath… - PLoS …, 2019 - journals.plos.org
The highly conserved proteins of the 14-3-3 family are universal adaptors known to regulate
an enormous range of cellular processes in eukaryotes. However, their biological functions …

An atypical EhGEF regulates phagocytosis in Entamoeba histolytica through EhRho1

R Bharadwaj, T Kushwaha, A Ahmad… - PLoS …, 2021 - journals.plos.org
The parasite Entamoeba histolytica is the etiological agent of amoebiasis, a major cause of
morbidity and mortality due to parasitic diseases in developing countries. Phagocytosis is an …