Illuminating RNA biology through imaging
RNA processing plays a central role in accurately transmitting genetic information into
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
functional RNA and protein regulators. To fully appreciate the RNA life-cycle, tools to …
Molecular mechanisms behind mRNA localization in axons
B Turner-Bridger, C Caterino, JM Cioni - Open biology, 2020 - royalsocietypublishing.org
Messenger RNA (mRNA) localization allows spatiotemporal regulation of the proteome at
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
the subcellular level. This is observed in the axons of neurons, where mRNA localization is …
Vagus nerve inflammation contributes to dysautonomia in COVID-19
Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom
burden after recovery from COVID-19 (long COVID), yet the underlying causes remain …
burden after recovery from COVID-19 (long COVID), yet the underlying causes remain …
mRNA transport, translation, and decay in adult mammalian central nervous system axons
Localized mRNA translation regulates synapse function and axon maintenance, but how
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …
compartment-specific mRNA repertoires are regulated is largely unknown. We developed an …
Messenger RNA transport on lysosomal vesicles maintains axonal mitochondrial homeostasis and prevents axonal degeneration
In neurons, RNA granules are transported along the axon for local translation away from the
soma. Recent studies indicate that some of this transport involves hitchhiking of RNA …
soma. Recent studies indicate that some of this transport involves hitchhiking of RNA …
On-site ribosome remodeling by locally synthesized ribosomal proteins in axons
Ribosome assembly occurs mainly in the nucleolus, yet recent studies have revealed robust
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …
enrichment and translation of mRNAs encoding many ribosomal proteins (RPs) in axons, far …
Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
D Jutzi, S Campagne, R Schmidt, S Reber… - Nature …, 2020 - nature.com
Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset
amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central RNA …
amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central RNA …
[HTML][HTML] Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
KS Dittlau, EN Krasnow, L Fumagalli, T Vandoorne… - Stem Cell Reports, 2021 - cell.com
Neuromuscular junctions (NMJs) ensure communication between motor neurons (MNs) and
muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs …
muscle; however, in MN disorders, such as amyotrophic lateral sclerosis (ALS), NMJs …
Neurofilament light regulates axon caliber, synaptic activity, and organelle trafficking in cultured human motor neurons
MT Sainio, T Rasila, SM Molchanova… - Frontiers in cell and …, 2022 - frontiersin.org
Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific
intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber …
intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber …
ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
Mutations in the RNA-binding protein (RBP) FUS have been genetically associated with the
motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced …
motoneuron disease amyotrophic lateral sclerosis (ALS). Using both human induced …