Heart failure is a pressing worldwide public-health problem with millions of patients having
worsening heart failure. Despite all the available therapies, the condition carries a very poor …

The potential beneficial effects of the antioxidant properties of vitamin C have been
investigated in a number of pathological conditions. In this review, we assess both clinical …

Diet is the only known intervention which has been conclusively shown to extend life span. It
can be argued the key role diet has to play in the aging process came to prominence as a …

Current scientific debates center on the impact of lipids and mitochondrial function on
diverse aspects of human health, nutrition and disease, among them the association of …

Cardiomyocyte function depends on coordinated movements of calcium into and out of the
cell and the proper delivery of ATP to energy-utilizing enzymes. Defects in calcium-handling …

Cardiac arrhythmias can cause sudden cardiac death (SCD) and add to the current heart
failure (HF) health crisis. Nevertheless, the pathological processes underlying arrhythmias …

Mitochondria are strategically and dynamically positioned in the cell to spatially coordinate
ATP production with energy needs and to allow the local exchange of material with other …

Background: Cardiac arrhythmias represent a significant problem globally, leading to
cerebrovascular accidents, myocardial infarction, and sudden cardiac death. There is …

The net emission of hydrogen peroxide (H2O2) from mitochondria results from the balance
between reactive oxygen species (ROS) continuously generated in the respiratory chain and …

The pineal gland is a neuroendocrine gland which produces melatonin, a neuroendocrine
hormone with critical physiological roles in the circadian rhythm and sleep-wake cycle …