Although polyenes were the first broad spectrum antifungal drugs on the market, after 70
years they are still the gold standard to treat a variety of fungal infections. Polyenes such as …

Understanding of the taxonomy and phylogeny of Cryptococcus gattii has been advanced by
modern molecular techniques. C. gattii probably diverged from Cryptococcus neoformans …

With increasing numbers of immune-compromised patients with malignancy, hematologic
disease, and HIV, as well as those receiving immunosupressive drug regimens for the …

The incidence of invasive mycoses is increasing, especially among patients who are
immunocompromised or hospitalized with serious underlying diseases. Such infections may …

Amphotericin B (AmB), a broad-spectrum polyene antibiotic in the clinic for more than fifty
years, remains the gold standard in the treatment of life-threatening invasive fungal …

Fungal pathogens are a growing threat to public health. As human immunodeficiency
becomes increasingly common, fungal infections are becoming more prevalent. The use of …

Epidemiological cutoff values (ECVs) for the Cryptococcus neoformans-Cryptococcus gattii
species complex versus fluconazole, itraconazole, posaconazole, and voriconazole are not …

Effective management and treatment of fungal diseases is hampered by poor diagnosis,
limited options for antifungal therapy, and the emergence of antifungal drug resistance. An …

The commercial technique Vitek 2 system for antifungal susceptibility testing of yeast
species was evaluated. A collection of 154 clinical yeast isolates, including amphotericin B …

We discovered a new lineage of the globally important fungal pathogen Cryptococcus gattii
on the basis of analysis of six isolates collected from three locations spanning the Central …