The Notch/Lin-12/Glp-1 receptor family mediates the specification of numerous cell fates
during development in Drosophila and Caenorhabditis elegans. Studies on the expression …

Notch signaling induced by canonical Notch ligands is critical for normal embryonic
development and tissue homeostasis through the regulation of a variety of cell fate decisions …

The germ line of the nematode Caenorhabditis elegans influences life-span; when the germ-
line precursor cells are removed, life-span is increased dramatically. We find that neither …

The nematode Caenorhabditis elegans was chosen as a model genetic organism because
its attributes, chiefly its hermaphroditic lifestyle and rapid generation time, make it suitable …

Members of the Notch family of transmembrane receptors mediate a number of
developmental decisions in invertebrates. In order to study Notch function in a vertebrate …

We report the cloning and characterization of a new member of the Delta family of Notch
ligands, which we have named Dll4. Like other Delta genes, Dll4 is predicted to encode a …

Previous studies have shown that blocking DLL4 signaling reduced tumor growth by
disrupting productive angiogenesis. We developed selective anti-human and anti-mouse …

THE product of the Delta gene, acting as ligand, and that of the Notch gene, acting as
receptor, are key components in a lateral-inhibition signalling pathway that regulates the …

Here we report the isolation of a rat cDNA clone, Jagged, which we show encodes a ligand
for vertebrate Notch. Our conclusion is based on three observations. First, sequence …

The C. elegans lag-2 gene is required for several cell-cell interactions that rely on the
receptors GLP-1 and LIN-12. In this paper, we report that lag-2 encodes a putative …