Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

The ability of double-stranded DNA to form a triple-helical structure by hydrogen bonding
with a third strand is well established, but the biological functions of these structures remain …

Epigenetic processes play a key role in orchestrating transcriptional regulation during
development. The importance of DNA methylation in fetal brain development is highlighted …

The human prefrontal cortex (PFC), a mastermind of the brain, is one of the last brain
regions to mature. To investigate the role of epigenetics in the development of PFC, we …

Potential adverse effects of excess maternal folic acid supplementation on a vegetarian
population deficient in vitamin B12 are poorly understood. We have previously shown in a …

Disruption of the epigenetic program of gene expression is a hallmark of cancer that initiates
and propagates tumorigenesis. Altered DNA methylation, histone modifications and ncRNAs …

Cytosine methylation is an epigenetic modification of DNA catalyzed by DNA
methyltransferases. Cytosine methylation of mitochondrial DNA (mtDNA) is believed to have …

Several studies have proved that DNA methylation affects regulation of gene expression and
development. Epigenome-wide studies have reported variation in methylation patterns …

Background: Arsenic is an epigenetic toxicant and could influence fetal developmental
programming. Objectives: We evaluated the association between arsenic exposure and …

Homocysteine is a metabolite generated by methionine cycle metabolism, comprising the
demethylated derivative of methionine. Homocysteine can be metabolised by the …