Parcellating cerebral cortex: how invasive animal studies inform noninvasive mapmaking in humans

DC Van Essen, MF Glasser - Neuron, 2018 - cell.com
The cerebral cortex in mammals contains a mosaic of cortical areas that differ in function,
architecture, connectivity, and/or topographic organization. A combination of local …

Spontaneous behaviors drive multidimensional, brainwide activity

C Stringer, M Pachitariu, N Steinmetz, CB Reddy… - Science, 2019 - science.org
INTRODUCTION In the absence of sensory inputs, the brain produces structured patterns of
activity, which can be as large as or larger than sensory-driven activity. Ongoing activity …

mTOR-related synaptic pathology causes autism spectrum disorder-associated functional hyperconnectivity

M Pagani, N Barsotti, A Bertero, S Trakoshis… - Nature …, 2021 - nature.com
Postmortem studies have revealed increased density of excitatory synapses in the brains of
individuals with autism spectrum disorder (ASD), with a putative link to aberrant mTOR …

Molecular atlas of the adult mouse brain

C Ortiz, JF Navarro, A Jurek, A Märtin, J Lundeberg… - Science …, 2020 - science.org
Brain maps are essential for integrating information and interpreting the structure-function
relationship of circuits and behavior. We aimed to generate a systematic classification of the …

[HTML][HTML] Apical drive—A cellular mechanism of dreaming?

J Aru, F Siclari, WA Phillips, JF Storm - Neuroscience & Biobehavioral …, 2020 - Elsevier
Dreams are internally generated experiences that occur independently of current sensory
input. Here we argue, based on cortical anatomy and function, that dream experiences are …

Multimodal gradients across mouse cortex

BD Fulcher, JD Murray, V Zerbi… - Proceedings of the …, 2019 - National Acad Sciences
The primate cerebral cortex displays a hierarchy that extends from primary sensorimotor to
association areas, supporting increasingly integrated function underpinned by a gradient of …

Cerebral cortical folding, parcellation, and connectivity in humans, nonhuman primates, and mice

DC Van Essen, CJ Donahue… - Proceedings of the …, 2019 - National Acad Sciences
Advances in neuroimaging and neuroanatomy have yielded major insights concerning
fundamental principles of cortical organization and evolution, thus speaking to how well …

Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines

F Ali, DM Gerhard, K Sweasy, S Pothula… - Nature …, 2020 - nature.com
A subanesthetic dose of ketamine causes acute psychotomimetic symptoms and sustained
antidepressant effects. In prefrontal cortex, the prevailing disinhibition hypothesis posits that …

Higher-order thalamic circuits channel parallel streams of visual information in mice

C Bennett, SD Gale, ME Garrett, ML Newton… - Neuron, 2019 - cell.com
Higher-order thalamic nuclei, such as the visual pulvinar, play essential roles in cortical
function by connecting functionally related cortical and subcortical brain regions. A coherent …

Inhibition stabilization is a widespread property of cortical networks

A Sanzeni, B Akitake, HC Goldbach, CE Leedy… - Elife, 2020 - elifesciences.org
Many cortical network models use recurrent coupling strong enough to require inhibition for
stabilization. Yet it has been experimentally unclear whether inhibition-stabilized network …