Invasive fungal infections are associated with high mortality rates, despite appropriate
antifungal therapy. Limited therapeutic options, resistance development and the high …

More than a thousand antimicrobial peptides (AMPs) have been reported in the last decades
arising from the skin secretion of amphibian species. Generally, each frog species can …

The COVID-19 pandemic has evidenced the urgent need for the discovery of broad-
spectrum antiviral therapies that could be deployed in the case of future emergence of novel …

We have developed a new concept for reversible peptide stapling that involves
macrocyclization between two amino groups and decyclization promoted via dual 1, 4 …

In an era where the pipeline of new antibiotic development is drying up, the continuous rise
of multi-drug resistant (MDR) and extensively drug resistant (XDR) bacteria are genuine …

The high-resolution three-dimensional structure of an antimicrobial peptide has implications
for the mechanism of its antimicrobial activity, as the conformation of the peptide provides …

The pharmacodynamic and pharmacokinetic properties of bioactive peptides can be
modulated by introducing conformational constraints such as intramolecular …

Temporins constitute a family of amphipathic α-helical antimicrobial peptides (AMP) and
contain some of the shortest cytotoxic peptides, comprised of only 10–14 residues. General …

Membranolytic anticancer peptides (ACPs) potentially offer new perspectives for the
development of anticancer drugs. Their receptor-independent mechanisms of action hold …

Antimicrobial peptides (AMPs) attack bacterial membranes selectively, killing microbes at
concentrations that cause no toxicity to the host cells. This selectivity is not due to interaction …