Lower body negative pressure: physiological effects, applications, and implementation

N Goswami, AP Blaber… - Physiological …, 2019 - journals.physiology.org
This review presents lower body negative pressure (LBNP) as a unique tool to investigate
the physiology of integrated systemic compensatory responses to altered hemodynamic …

Dehydration: physiology, assessment, and performance effects

SN Cheuvront, RW Kenefick - Comprehensive Physiology, 2011 - Wiley Online Library
This article provides a comprehensive review of dehydration assessment and presents a
unique evaluation of the dehydration and performance literature. The importance of …

The compensatory reserve for early and accurate prediction of hemodynamic compromise: a review of the underlying physiology

VA Convertino, MD Wirt, JF Glenn, BC Lein - Shock, 2016 - journals.lww.com
Shock is deadly and unpredictable if it is not recognized and treated in early stages of
hemorrhage. Unfortunately, measurements of standard vital signs that are displayed on …

The physiology of blood loss and shock: new insights from a human laboratory model of hemorrhage

AM Schiller, JT Howard… - … Biology and Medicine, 2017 - journals.sagepub.com
The ability to quickly diagnose hemorrhagic shock is critical for favorable patient outcomes.
Therefore, it is important to understand the time course and involvement of the various …

Validation of lower body negative pressure as an experimental model of hemorrhage

C Hinojosa-Laborde, RE Shade… - Journal of Applied …, 2014 - journals.physiology.org
Lower body negative pressure (LBNP), a model of hemorrhage (Hem), shifts blood to the
legs and elicits central hypovolemia. This study compared responses to LBNP and actual …

Estimation of individual-specific progression to impending cardiovascular instability using arterial waveforms

VA Convertino, G Grudic, J Mulligan… - Journal of Applied …, 2013 - journals.physiology.org
Trauma patients with “compensated” internal hemorrhage may not be identified with
standard medical monitors until signs of shock appear, at which point it may be difficult or too …

Reductions in central venous pressure by lower body negative pressure or blood loss elicit similar hemodynamic responses

BD Johnson, N Van Helmond… - Journal of applied …, 2014 - journals.physiology.org
The purpose of this study was to compare hemodynamic and blood analyte responses to
reduced central venous pressure (CVP) and pulse pressure (PP) elicited during graded …

Running on empty? The compensatory reserve index

SL Moulton, J Mulligan, GZ Grudic… - Journal of Trauma and …, 2013 - journals.lww.com
BACKGROUND Hemorrhage is a leading cause of traumatic death. We hypothesized that
state-of-the-art feature extraction and machine learning techniques could be used to …

Mechanisms of orthostatic intolerance during heat stress

ZJ Schlader, TE Wilson, CG Crandall - Autonomic Neuroscience, 2016 - Elsevier
Heat stress profoundly and unanimously reduces orthostatic tolerance. This review aims to
provide an overview of the numerous and multifactorial mechanisms by which this occurs in …

Individual-specific, beat-to-beat trending of significant human blood loss: the compensatory reserve

VA Convertino, JT Howard, C Hinojosa-Laborde… - Shock, 2015 - journals.lww.com
Current monitoring technologies are unable to detect early, compensatory changes that are
associated with significant blood loss. We previously introduced a novel algorithm to …