Half a century of amyloids: past, present and future
Amyloid diseases are global epidemics with profound health, social and economic
implications and yet remain without a cure. This dire situation calls for research into the …
implications and yet remain without a cure. This dire situation calls for research into the …
Food protein aggregation and its application
Z Zhu, AP Bassey, Y Cao, Y Ma, M Huang… - Food research …, 2022 - Elsevier
The phenomenon of protein aggregation in food science is very common, but the formation
mechanism is unclear. The formation of protein aggregates (PAs) is influenced by various …
mechanism is unclear. The formation of protein aggregates (PAs) is influenced by various …
The amyloid state and its association with protein misfolding diseases
TPJ Knowles, M Vendruscolo… - Nature reviews Molecular …, 2014 - nature.com
The phenomenon of protein aggregation and amyloid formation has become the subject of
rapidly increasing research activities across a wide range of scientific disciplines. Such …
rapidly increasing research activities across a wide range of scientific disciplines. Such …
Mitochondrial dysfunction and oxidative stress in Parkinson's disease
SR Subramaniam, MF Chesselet - Progress in neurobiology, 2013 - Elsevier
Parkinson's disease (PD) is a movement disorder that is characterized by the progressive
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
degeneration of dopaminergic neurons in substantia nigra pars compacta resulting in …
Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia
Abnormal aggregation of α-synuclein and sustained microglial activation are important
contributors to the pathogenic processes of Parkinson's disease. However, the relationship …
contributors to the pathogenic processes of Parkinson's disease. However, the relationship …
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization
IW Hamley - Chemical reviews, 2012 - ACS Publications
This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …
α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation
Parkinson's disease is the second most common neurodegenerative disorder,. Growing
evidence indicates a causative role of misfolded forms of the protein α-synuclein in the …
evidence indicates a causative role of misfolded forms of the protein α-synuclein in the …
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Amyotrophic lateral sclerosis (ALS) is a paralytic and usually fatal disorder caused by motor-
neuron degeneration in the brain and spinal cord. Most cases of ALS are sporadic but about …
neuron degeneration in the brain and spinal cord. Most cases of ALS are sporadic but about …
On the lag phase in amyloid fibril formation
P Arosio, TPJ Knowles, S Linse - Physical Chemistry Chemical Physics, 2015 - pubs.rsc.org
The formation of nanoscale amyloid fibrils from normally soluble peptides and proteins is a
common form of self-assembly phenomenon that has fundamental connections with …
common form of self-assembly phenomenon that has fundamental connections with …
Protein interaction networks in neurodegenerative diseases: From physiological function to aggregation
G Calabrese, C Molzahn, T Mayor - Journal of Biological Chemistry, 2022 - ASBMB
The accumulation of protein inclusions is linked to many neurodegenerative diseases that
typically develop in older individuals, due to a combination of genetic and environmental …
typically develop in older individuals, due to a combination of genetic and environmental …