Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

Cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP)(cGAMP)
synthase (cGAS), along with the adaptor stimulator of interferon genes (STING), are crucial …

Periodontal disease is one of the most common oral infectious diseases and closely related
to many systemic diseases which is in urgent need of novel and effective drugs. In particular …

Background Nod‐like receptor family pyrin domain‐containing protein‐3 (NLRP3) complex
inflammasome has potentially been shown to play an important role in the development of …

Periodontitis is defined as a chronic inflammatory disease in which the continuous activation
of oxidative stress surpasses the reactive oxygen species (ROS) scavenging capacity of the …

Objective The aim of this study was to analyze and identify the association among salivary
interleukin-6 (IL-6) levels and periodontitis (PT) and to determine the significant trend of this …

Chronic inflammatory processes in the oral mucosa and periodontitis are common disorders
caused by microflora and microbial biofilms. These factors activate both the innate and …

There is growing evidence on the involvement of oxidative stress, which is simply described
as the imbalance between oxidants and antioxidants in favor of the former, in the …

Alcoholism is one of the most common diseases that can lead to the development of several
chronic diseases including steatosis, and cognitive dysfunction. Statins are lipid-lowering …

A20 is involved in inflammation and bone metabolism in periodontitis. Regulation of
macrophage polarization may be an effective target for periodontitis treatment, and A20 has …