The landscape of aging

Y Cai, W Song, J Li, Y Jing, C Liang, L Zhang… - Science China Life …, 2022 - Springer
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Ageing populations: the challenges ahead

K Christensen, G Doblhammer, R Rau, JW Vaupel - The lancet, 2009 - thelancet.com
If the pace of increase in life expectancy in developed countries over the past two centuries
continues through the 21st century, most babies born since 2000 in France, Germany, Italy …

Aging, frailty, and the microbiome—how dysbiosis influences human aging and disease

JP Haran, BA McCormick - Gastroenterology, 2021 - Elsevier
The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …

Gut microbiota signatures of longevity

F Kong, Y Hua, B Zeng, R Ning, Y Li, J Zhao - Current Biology, 2016 - cell.com
An aging global population poses substantial challenges to society [1]. Centenarians are a
model for healthy aging because they have reached the extreme limit of life by escaping …

Age-dependent changes in GI physiology and microbiota: time to reconsider?

R An, E Wilms, AAM Masclee, H Smidt, EG Zoetendal… - Gut, 2018 - gut.bmj.com
Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is
associated with a decline in physiological function and adaptive capacity. Altered GI …

Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity

DR Seals, JN Justice, TJ LaRocca - The Journal of physiology, 2016 - Wiley Online Library
Most nations of the world are undergoing rapid and dramatic population ageing, which
presents great socio‐economic challenges, as well as opportunities, for individuals, families …

Lay perspectives of successful ageing: a systematic review and meta-ethnography

TD Cosco, AM Prina, J Perales, BCM Stephan… - BMJ open, 2013 - bmjopen.bmj.com
Objectives The aim of the current study was to conduct a systematic review of lay
perspectives of successful ageing (SA), synthesise these data using a metaethnographic …

Dynamic DNA methylation during aging: a “prophet” of age-related outcomes

FH Xiao, HT Wang, QP Kong - Frontiers in genetics, 2019 - frontiersin.org
The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Friend or foe? Defining the role of glutamate in aging and Alzheimer's disease

MKF Cox, ER Hascup, A Bartke, KN Hascup - Frontiers in Aging, 2022 - frontiersin.org
Aging is a naturally occurring decline of physiological processes and biological pathways
that affects both the structural and functional integrity of the body and brain. These …

ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity

FH Xiao, Q Yu, ZL Deng, K Yang, Y Ye, MX Ge… - Science …, 2022 - science.org
Adaptation to reduced energy production during aging is a fundamental issue for
maintaining healthspan or prolonging life span. Currently, however, the underlying …