In this review, advances in the understanding of epigenetic reprogramming from fertilization
to the development of primordial germline cells in a mouse and human embryo are …

The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and
TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly …

Background Perturbation of DNA methyltransferases (DNMTs) and of the active DNA
demethylation pathway via ten-eleven translocation (TET) methylcytosine dioxygenases …

Loss of function TET2 mutation (TET2 MT) is one of the most frequently observed lesions in
clonal haematopoiesis (CH). TET2 a member TET-dioxygenase family of enzyme that along …

During embryo development, DNA methylation is established by DNMT3A/3B and
subsequently maintained by DNMT1. While much research has been done in this field, the …

DNA methylation is extensively reconfigured during development, but the functional
significance and cell type–specific dependencies of DNA demethylation in lineage …

Ten eleven translocation 1 (Tet1) is a DNA dioxygenase that promotes DNA demethylation
by oxidizing 5-methylcytosine. It can also partner with chromatin-activating and repressive …

Maintaining healthy adipose tissue is crucial for metabolic health, requiring a deeper
understanding of adipocyte development and response to high-calorie diets. This study …

Innate lymphoid cell precursors (ILCPs) develop into distinct subsets of innate lymphoid
cells (ILCs) with specific functions. The epigenetic program underlying the differentiation of …

The ten-eleven-translocation family of proteins (TET1/2/3) are epigenetic regulators of gene
expression. They regulate genes by promoting DNA demethylation (ie, catalytic activity) and …