Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

HC Nguyen, JC Frisbee, KK Singh - Hearts, 2024 - mdpi.com
Germline mutations in Breast cancer susceptibility genes 1 and 2 (BRCA1 and BRCA2)
cause breast, ovarian, and other cancers, and the chemotherapeutic drug doxorubicin (Dox) …

The oxidized phospholipid PGPC impairs endothelial function by promoting endothelial cell ferroptosis via FABP3

S Chen, JJ Gao, YJ Liu, ZW Mo, FY Wu, ZJ Hu… - Journal of Lipid …, 2024 - ASBMB
Ferroptosis is a novel cell death mechanism that is mediated by iron-dependent lipid
peroxidation. It may be involved in atherosclerosis development. Products of phospholipid …

Protein Disulfide Isomerase 4 Is an Essential Regulator of Endothelial Function and Survival

S Bu, A Singh, HC Nguyen, B Peddi, K Bhatt… - International Journal of …, 2024 - mdpi.com
Endothelial autophagy plays an important role in the regulation of endothelial function. The
inhibition of endothelial autophagy is associated with the reduced expression of protein …

Endothelial dysfunction: mechanisms and contribution to diseases

A Ajoolabady, D Pratico, J Ren - Acta Pharmacologica Sinica, 2024 - nature.com
The endothelium, lining the inner surface of blood vessels and spanning approximately 3
m2, serves as the largest organ in the body. Comprised of endothelial cells, the endothelium …

Intermediate Monocytes and Circulating Endothelial Cells: Interplay with Severity of Atherosclerosis in Patients with Coronary Artery Disease and Type 2 Diabetes …

IV Kologrivova, TE Suslova, OA Koshelskaya… - Biomedicines, 2023 - mdpi.com
The aim was to investigate the association of monocyte heterogeneity and presence of
circulating endothelial cells with the severity of coronary atherosclerosis in patients with …