The eXtensible ontology development (XOD) principles and tool implementation to support ontology interoperability

Y He, Z Xiang, J Zheng, Y Lin, JA Overton… - Journal of biomedical …, 2018 - Springer
Ontologies are critical to data/metadata and knowledge standardization, sharing, and
analysis. With hundreds of biological and biomedical ontologies developed, it has become …

[HTML][HTML] Patient safety classifications, taxonomies and ontologies: A systematic review on development and evaluation methodologies

ST Moghadam, N Hooman, A Sheikhtaheri - Journal of Biomedical …, 2022 - Elsevier
Introduction Patient safety classifications/ontologies enable patient safety information
systems to receive and analyze patient safety data to improve patient safety. Patient safety …

Ontological modeling and analysis of experimentally or clinically verified drugs against coronavirus infection

Y Liu, J Hur, WKB Chan, Z Wang, J Xie, D Sun… - Scientific data, 2021 - nature.com
Our systematic literature collection and annotation identified 106 chemical drugs and 31
antibodies effective against the infection of at least one human coronavirus (including SARS …

Ontological and bioinformatic analysis of anti-coronavirus drugs and their implication for drug repurposing against COVID-19

Y Liu, W Chan, Z Wang, J Hur, J Xie, H Yu, Y He - 2020 - preprints.org
Coronavirus-infected diseases have posed great threats to human health. In past years,
highly infectious coronavirus-induced diseases, including COVID-19, SARS, and MERS …

Machine learning-based identification and rule-based normalization of adverse drug reactions in drug labels

M Tiftikci, A Özgür, Y He, J Hur - BMC bioinformatics, 2019 - Springer
Background Use of medication can cause adverse drug reactions (ADRs), unwanted or
unexpected events, which are a major safety concern. Drug labels, or prescribing …

Patient safety classifications, taxonomies and ontologies, Part 2: A systematic review on content coverage

ST Moghadam, A Sheikhtaheri, N Hooman - Journal of Biomedical …, 2023 - Elsevier
Background Content coverage of patient safety ontology and classification systems should
be evaluated to provide a guide for users to select appropriate ones for specific applications …

Ontology-based systematical representation and drug class effect analysis of package insert-reported adverse events associated with cardiovascular drugs used in …

L Wang, M Li, J Xie, Y Cao, H Liu, Y He - Scientific reports, 2017 - nature.com
With increased usage of cardiovascular drugs (CVDs) for treating cardiovascular diseases, it
is important to analyze CVD-associated adverse events (AEs). In this study, we …

[HTML][HTML] Computational advances in drug safety: systematic and mapping review of knowledge engineering based approaches

P Natsiavas, A Malousi, C Bousquet… - Frontiers in …, 2019 - frontiersin.org
Drug Safety (DS) is a domain with significant public health and social impact. Knowledge
Engineering (KE) is the Computer Science discipline elaborating on methods and tools for …

ODAE: Ontology-based systematic representation and analysis of drug adverse events and its usage in study of adverse events given different patient age and …

H Yu, S Nysak, N Garg, E Ong, X Ye, X Zhang, Y He - BMC bioinformatics, 2019 - Springer
Abstract Background Drug adverse events (AEs), or called adverse drug events (ADEs), are
ranked one of the leading causes of mortality. The Ontology of Adverse Events (OAE) has …

Text preprocessing for improving hypoglycemia detection from clinical notes–A case study of patients with diabetes

L Zhou, T Siddiqui, SL Seliger, JB Blumenthal… - International journal of …, 2019 - Elsevier
Background and objective Hypoglycemia is a common safety event when attempting to
optimize glycemic control in diabetes (DM). While electronic medical records provide a …