Investigations into the interaction between radiotherapy and the host immune system have
uncovered new mechanisms that can potentially be exploited to improve the efficacy of …

Interferon-γ (IFN-γ) is a pleiotropic cytokine that has long been praised as an important
effector molecule of anti-tumor immunity, capable of suppressing tumor growth through …

INTRODUCTION Dendritic cells (DCs) and monocytes consist of multiple specialized
subtypes that play a central role in pathogen sensing, phagocytosis, and antigen …

Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective
immunity to helminth infection and detrimentally during allergy and asthma. Using two …

Conventional chemotherapeutics and targeted antineoplastic agents have been developed
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …

With the advent of combined immunotherapies, personalized dendritic cell (DC)-based
vaccination could integrate the current standard of care for the treatment of a large variety of …

Accumulating evidence indicates that the innate and adaptive immune systems make a
crucial contribution to the antitumour effects of conventional chemotherapy-based and …

The functions and transcriptional profiles of dendritic cells (DCs) result from the interplay
between ontogeny and tissue imprinting. How tumors shape human DCs is unknown. Here …

Numerous innate and adaptive immune effector cells and molecules participate in the
recognition and destruction of cancer cells, a process that is known as cancer …

Cancer cells accommodate multiple genetic and epigenetic alterations that initially activate
intrinsic (cell-autonomous) and extrinsic (immune-mediated) oncosuppressive mechanisms …