Many different forms of hormonal contraception are used by millions of women worldwide.
These contraceptives differ in the dose and type of synthetic progestogenic compound …

Introduction: Africa harbors a disproportionate burden of disease when taking into account
the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop …

Background Warfarin dose variability observed in patients is attributed to variation in genes
involved in the warfarin metabolic pathway. Genetic variation in CYP2C9 and VKORC1 has …

Methods HIV/AIDS patients were recruited from Themba Lethu Clinic, at Helen Joseph
Hospital, Johannesburg. Blood samples for plasma drug levels and DNA extraction were …

South Africa, like many other developing countries, stands to benefit from novel diagnostics
and drugs developed by pharmacogenomics guidance due to high prevalence of disease …

Ketamine and its enantiomer S‐ketamine (esketamine) are known to produce rapid‐onset
antidepressant effects in major depression. Intranasal esketamine has recently come onto …

Aim: The frequencies of variants of pharmacogenetic importance differ across populations.
African populations exhibit the greatest genetic heterogeneity, cautioning against …

The ABCB1 gene encodes P-glycoprotein, an ATP-dependent drug efflux pump, which is
responsible for drug transport across extra-and intra-cellular membranes. The variability in …

Background This study investigated variation in NR1I2 and NR1I3 and its effect on plasma
efavirenz levels in HIV/AIDS patients. Variability in plasma drug levels has largely led …

Background Antiretroviral treatment is highly effective in enhancing HIV-positive patients'
survival and quality of life. Despite an increased tolerability in recent years, a substantial …