The discovery of leptin changed the view of adipose tissue from that of a passive vessel that
stores fat to that of a dynamic endocrine organ that actively regulates behaviour and …

Diabetes is a disease characterized by a relative or absolute lack of insulin, leading to
hyperglycaemia. There are two main types of diabetes: type 1 diabetes and type 2 diabetes …

Acquired resistance to the action of insulin to stimulate glucose transport in skeletal muscle
is associated with obesity and promotes the development of type 2 diabetes. In skeletal …

Aims/hypothesis Metabolic disorders are commonly investigated using knockout and
transgenic mouse models. A variety of mouse strains have been used for this purpose …

Obesity is a major public health concern. This condition results from a constant and complex
interplay between predisposing genes and environmental stimuli. Current attempts to …

Although medicinal plants have been historically used for diabetes treatment throughout the
world, few of them have been validated by scientific criteria. Recently, a large diversity of …

It is becoming increasingly apparent that the causes of autism spectrum disorders (ASD) are
due to both genetic and environmental factors. Animal studies provide important …

Metabolic syndrome (MetSyn) is a group of metabolic conditions that occur together and
promote the development of cardiovascular disease (CVD) and diabetes. Recent genome …

Insulin sensitizers like metformin generally act through pathways triggered by adenosine
monophosphate‐activated protein kinase. Carnitine palmitoyltransferase 1 (CPT1) controls …

While there are many murine models of mesangial matrix expansion in the setting of
diabetes, few progress to develop advanced diabetic lesions. Mice with eNOS deficiency …