Epithelial stem cells serve critical physiological functions in the generation, maintenance
and repair of diverse tissues through their ability to self-renew and spawn more specialized …

The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Microglia constitute a highly specialized network of tissue-resident immune cells that is
important for the control of tissue homeostasis and the resolution of diseases of the CNS …

The mammary gland is a highly dynamic organ that undergoes profound changes within its
epithelium during puberty and the reproductive cycle. These changes are fueled by …

Wound healing is essential to repair the skin after injury. In the epidermis, distinct stem cells
(SCs) populations contribute to wound healing. However, how SCs balance proliferation …

Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Prostate organogenesis is a complex process that is primarily mediated by the presence of
androgens and subsequent mesenchyme-epithelial interactions. The investigation of …

R-spondin (RSPO) proteins constitute a family of four secreted glycoproteins (RSPO1–4)
that have appeared as multipotent signaling ligands. The best-known molecular function of …

Research using animal model systems has been instrumental in delivering improved
therapies for breast cancer, as well as in generating new insights into the mechanisms that …

The mammary gland consists of cells with gene expression patterns reflecting their cellular
origins, function, and spatiotemporal context. However, knowledge of developmental …