Selenium is a trace mineral that is essential for health. After being obtained from food and
taken up by the liver, selenium performs various physiological functions in the body in the …

As cancer cells develop resistance to apoptosis, non-apoptotic cell death modalities, such
as ferroptosis, have emerged as promising strategies to combat therapy-resistant cancers …

The habitual intake of selenium (Se) varies strongly around the world, and many people are
at risk of inadequate supply and health risks from Se deficiency. Within the human organism …

Ferroptosis is a form of cell death that has received considerable attention not only as a
means to eradicate defined tumour entities but also because it provides unforeseen insights …

In cancer treatment, the recurrent challenge of inducing apoptosis through conventional
therapeutic modalities, often thwarted by therapy resistance, emphasizes the critical need to …

Selenophosphate synthetases use selenium and ATP to synthesize selenophosphate. This
is required for biological utilization of selenium, most notably for the synthesis of the non …

Supplementing chemotherapy and radiotherapy with selenium has been shown to have
benefits against various cancers. This approach has also been shown to alleviate the side …

Relapse of acute myeloid leukemia (AML) remains a significant concern due to persistent
leukemia-initiating stem cells (LICs) that are typically not targeted by most existing therapies …

Identification of specific and therapeutically actionable vulnerabilities, ideally present across
multiple mutational backgrounds, is needed to improve acute myeloid leukemia (AML) …

Cis-regulatory enhancers are essential for differential expression of developmental and
housekeeping genes. However, the specificity of native mammalian enhancers and how it …