Antiviral restriction factors are cellular proteins that inhibit the entry, replication, or spread of
viruses. These proteins are critical components of the innate immune system and function to …

Tetherin (BST2/CD317) has been recently recognized as a potent interferon-induced
antiviral molecule that inhibits the release of diverse mammalian enveloped virus particles …

Unlike activated CD4+ T cells, resting CD4+ T cells are highly resistant to productive HIV-1
infection,,,,,,,. Early after HIV-1 entry, a major block limits reverse transcription of incoming …

Human hepatitis B virus (HBV) and its satellite virus, hepatitis D virus (HDV), primarily infect
humans, chimpanzees, or tree shrews (Tupaia belangeri). Viral infections in other species …

The nucleoside analog cytarabine (Ara-C) is an essential component of primary and salvage
chemotherapy regimens for acute myeloid leukemia (AML). After cellular uptake, Ara-C is …

Direct cell-to-cell spread of human immunodeficiency virus type 1 (HIV-1) between T cells at
the virological synapse (VS) is an efficient mechanism of viral dissemination. Tetherin (BST …

Background Pancreatic ductal adenocarcinoma (PDAC) has little response to immune
checkpoint inhibitors. An in-depth understanding of the immune microenvironment from a …

Chikungunya virus (CHIKV) is a re-emerging alphavirus transmitted by Aedes mosquitoes.
Infection with CHIKV elicits a type I interferon response that facilities virus clearance …

Hypomethylating agents decitabine and azacytidine are regarded as interchangeable in the
treatment of acute myeloid leukemia (AML). However, their mechanisms of action remain …

The interferon-inducible restriction factor tetherin (also known as CD317, BST-2 or HM1. 24)
has emerged as a key component of the antiviral immune response. Initially, tetherin was …