Significant advances in our understanding of the in vivo functions of human cells and tissues
and the human immune system have resulted from the development of'humanized'mouse …

Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a
wide range of cells involved in the immune response. To efficiently infect humans, DENV …

The four dengue virus (DENV) serotypes that circulate among humans emerged
independently from ancestral sylvatic progenitors that were present in non-human primates …

To directly study complex human hemato-lymphoid system physiology and respective
system-associated diseases in vivo, human-to-mouse xenotransplantation models for …

Dengue viruses (DENV) are by far the most important arboviral pathogens in the tropics
around the world, putting at risk of infection nearly a third of the global human population …

Four families of enveloped RNA viruses, filoviruses, flaviviruses, arenaviruses, and
bunyaviruses, cause hemorrhagic fevers. These viruses are maintained in specific natural …

The rapid spread of dengue is a worldwide public health problem. In two clinical studies of
dengue in Managua, Nicaragua, we observed an abrupt increase in disease severity across …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Antiviral drug discovery is becoming increasingly important due to the global threat of viral
disease pandemics. Many members of the genus Flavivirus are significant human …