Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …

Recent data have expanded the concept that inflammation is a critical component of tumour
progression. Many cancers arise from sites of infection, chronic irritation and inflammation. It …

Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved
in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer …

Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic
chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis …

Increasing evidence from epidemiological, preclinical and clinical studies suggests that
dysregulated inflammatory response plays a pivotal role in a multitude of chronic ailments …

The oral epithelial barrier separates the host from the environment and provides the first line
of defense against pathogens, exogenous substances and mechanical stress. It consists of …

Chemokines play a paramount role in the tumor progression. Chronic inflammation
promotes tumor formation. Both tumor cells and stromal cells elaborate chemokines and …

A variety of factors have been identified that regulate angiogenesis, including the CXC
chemokine family. The CXC chemokines are a unique family of cytokines for their ability to …