Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

Attempts to correlate protein abundance with mRNA expression levels have had variable
success. We review the results of these comparisons, focusing on yeast. In the process, we …

Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling,
and their dysfunction has been linked to numerous diseases. The available studies cover …

Information on protein subcellular localization is important to understand the cellular
functions of proteins. Currently, such information is manually curated from the literature …

Efforts to improve the production of a compound of interest in Saccharomyces cerevisiae
have mainly involved engineering or overexpression of cytoplasmic enzymes. We show that …

WoLF PSORT is an extension of the PSORT II program for protein subcellular location
prediction. WoLF PSORT converts protein amino acid sequences into numerical localization …

A fundamental goal of cell biology is to define the functions of proteins in the context of
compartments that organize them in the cellular environment. Here we describe the …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Determining the subcellular localization of a protein is an important first step toward
understanding its function. Here, we describe the properties of three well-known N-terminal …

Recent concerns over the sustainability of petrochemical-based processes for production of
desired chemicals have fueled research into alternative modes of production. Metabolic …