The high chemical complexity of the lipidome is one of the major challenges in lipidomics
research. Ion-mobility spectrometry (IMS), a gas-phase electrophoretic technique, makes …

Over the last decade, the development and prevalence of obesity have posed a serious
public health risk, which has prompted studies on the regulation of adiposity. With the ease …

Drugs that target histone deacetylase (HDAC) entered the pharmacopoeia in the 2000s.
However, some enigmatic phenotypes suggest off-target engagement. Here, we developed …

Diet can influence the composition of the human microbiome, and yet relatively few dietary
ingredients have been systematically investigated with respect to their impact on the …

Metabolomics and lipidomics aim to profile the wide range of metabolites and lipids that are
present in biological samples. Recently, ion mobility spectrometry (IMS) has been used to …

Reversed-phase ultrahigh-performance liquid chromatography–mass spectrometry (UHPLC–
MS) is the method of choice for lipidomic profiling of blood plasma. For comprehensive …

The goal of untargeted lipidomics is to have high throughput, yet comprehensive and
unambiguous identification and quantification of lipids. Novel stationary phases in LC …

An improved approach for selective and sensitive identification and quantitation of lipid
molecular species using reversed phase chromatography coupled to high resolution mass …

Lipid identification and quantification are essential objectives in comprehensive lipidomics
studies challenged by the high number of lipids, their chemical diversity, and their dynamic …

Lipids represent a very diverse group of compounds with a high variety of physicochemical
properties determining their functional activities. For omics-wide identification of lipid …