Lamellipodia, filopodia and membrane ruffles are essential for cell motility, the organization
of membrane domains, phagocytosis and the development of substrate adhesions. Their …

SUMMARY The Bin1/amphiphysin/Rvs167 (BAR) domain proteins are a ubiquitous protein
family. Genes encoding members of this family have not yet been found in the genomes of …

▪ Abstract The vacuole/lysosome of the budding yeast Saccharomyces cerevisiae is actively
divided between mother and daughter cells. Vacuole inheritance initiates early in the cell …

Myosins comprise a family of ATP-dependent motor proteins that are best known for their
role in muscle contraction and their involvement in a wide range of other eukaryotic motility …

Class V myosins are actin-based motor proteins that have critical functions in organelle
trafficking. Of the three class V myosins expressed in mammals, relatively little is known …

Recent experiments, drawing upon single-molecule, solution kinetic and structural
techniques, have clarified our mechanistic understanding of class V myosins. The findings of …

It has been known that the phosphorylation of the regulatory light chain, residing at the
head/rod junction of the molecule activates the motor activity of smooth muscle and non …

Class V myosins are motor proteins with functions in vesicle transport, organelle
segregation, and RNA localization. Although they have been extensively studied, only little …

Organelle inheritance occurs during cell division. In Saccharomyces cerevisiae, inheritance
of the vacuole, and the distribution of mitochondria and cortical endoplasmic reticulum are …

p53 is a central player in responses to cellular stresses and a major tumor suppressor. The
identification of unique molecules within the p53 signaling network can reveal functions of …