Local intracellular Ca2+ transients, termed Ca2+ sparks, are caused by the coordinated
opening of a cluster of ryanodine-sensitive Ca2+ release channels in the sarcoplasmic …

The sarcoplasmic reticulum (SR) of smooth muscles presents many intriguing facets and
questions concerning its roles, especially as these change with development, disease, and …

▪ Abstract The main contributors to increases in [Ca2+] i and tension are the entry of Ca2+
through voltage-dependent channels opened by depolarization or during action potential …

Kuriyama, H., K. Kitamura, T. Itoh, and R. Inoue. Physiological Features of Visceral Smooth
Muscle Cells, With Special Reference to Receptors and Ion Channels. Physiol. Rev. 78: 811 …

Intracellular calcium ions are involved in the regulation of nearly every aspect of cell
function. In smooth muscle, Ca2+ can be delivered to Ca2+-sensitive effector molecules …

Ca2+-activated Cl− channels control electrical excitability in various peripheral and central
populations of neurons. Ca2+ influx through voltage-gated or ligand-operated channels, as …

Intracellular Ca2+ concentration ([Ca2+] i) plays a central role in regulating tone and
contractility of smooth muscle cells. In contrast to the “classic” model of electromechanical …

▪ Abstract Ion channels are the unitary elements that underlie electrical activity of
gastrointestinal smooth muscle cells and of interstitial cells of Cajal. The result of ion …

In smooth muscle tissues, calcium-activated chloride channels (CaCC) provide the major
anionic channel. Opening of these channels leads to chloride efflux and depolarization of …

1. The perforated patch and conventional whole‐cell recording techniques were used to
study the action of flufenamic, mefenamic and niflumic acid on calcium‐activated chloride …