[HTML][HTML] Desaturases and elongases involved in long-chain polyunsaturated fatty acid biosynthesis in aquatic animals: From genes to functions

Ó Monroig, AC Shu-Chien, N Kabeya, DR Tocher… - Progress in lipid …, 2022 - Elsevier
Marine ecosystems are rich in “omega-3” long-chain (C 20-24) polyunsaturated fatty acids
(LC-PUFA). Their production has been historically accepted to derive mostly from marine …

Long-chain polyunsaturated fatty acid biosynthesis in chordates: Insights into the evolution of Fads and Elovl gene repertoire

LFC Castro, DR Tocher, O Monroig - Progress in lipid research, 2016 - Elsevier
Long-chain polyunsaturated fatty acids (LC-PUFA) are major components of complex lipid
molecules and are also involved in numerous critical biological processes. Studies …

Regulation of long-chain polyunsaturated fatty acid biosynthesis in teleost fish

D Xie, C Chen, Y Dong, C You, S Wang… - Progress in Lipid …, 2021 - Elsevier
Abstract Omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA, C 20-24),
including eicosapentaenoic acid (EPA, 20: 5n-3) and docosahexaenoic acid (DHA, 22: 6n …

Desaturases and elongases involved in polyunsaturated fatty acid biosynthesis in aquatic invertebrates: a comprehensive review

Ó Monroig, N Kabeya - Fisheries Science, 2018 - Springer
Invertebrates represent a large proportion of the biomass in aquatic ecosystems, particularly
in the ocean. In recent years, invertebrates have been well-consolidated models in …

[HTML][HTML] Two alternative pathways for docosahexaenoic acid (DHA, 22: 6n-3) biosynthesis are widespread among teleost fish

A Oboh, N Kabeya, G Carmona-Antoñanzas… - Scientific reports, 2017 - nature.com
Docosahexaenoic acid (DHA) plays important physiological roles in vertebrates. Studies in
rats and rainbow trout confirmed that DHA biosynthesis proceeds through the so-called …

[HTML][HTML] The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human …

HG Park, WJ Park, KSD Kothapalli… - The FASEB Journal, 2015 - ncbi.nlm.nih.gov
Docosahexaenoic acid (DHA) is a Δ4-desaturated C22 fatty acid and the limiting highly
unsaturated fatty acid (HUFA) in neural tissue. The biosynthesis of Δ4-desaturated …

Molecular mechanisms for biosynthesis and assembly of nutritionally important very long chain polyunsaturated fatty acids in microorganisms

X Qiu, X Xie, D Meesapyodsuk - Progress in Lipid Research, 2020 - Elsevier
Very long chain polyunsaturated fatty acids (VLCPUFAs) such as docosahexaenoic acid
(DHA, 22: 6n-3), arachidonic acid (ARA, 20: 4n-6) and eicosapentaenoic acid (EPA, 20: 5 …

Functional characterization and differential nutritional regulation of putative Elovl5 and Elovl4 elongases in large yellow croaker (Larimichthys crocea)

S Li, Ó Monroig, T Wang, Y Yuan, J Carlos Navarro… - Scientific reports, 2017 - nature.com
In the present study, two elongases, Elovl4 and Elovl5, were functionally characterized and
their transcriptional regulation in response to n-3 LC-PUFA administration were investigated …

The capacity for long-chain polyunsaturated fatty acid synthesis in a carnivorous vertebrate: Functional characterisation and nutritional regulation of a Fads2 fatty acyl …

MK Kuah, A Jaya-Ram, AC Shu-Chien - Biochimica et Biophysica Acta …, 2015 - Elsevier
The endogenous production of long-chain polyunsaturated fatty acids (LC-PUFA) in
carnivorous teleost species inhabiting freshwater environments is poorly understood …

New insights on intermediary metabolism for a better understanding of nutrition in teleosts

S Panserat, L Marandel, I Seiliez… - Annual review of …, 2019 - annualreviews.org
The rapid development of aquaculture production throughout the world over the past few
decades has led to the emergence of new scientific challenges to improve fish nutrition. The …