The recent identification of cannabinoid receptors and their endogenous lipid ligands has
triggered an exponential growth of studies exploring the endocannabinoid system and its …

The superfamily of phospholipase A2 (PLA2) enzymes currently consists of 15 Groups and
many subgroups and includes five distinct types of enzymes, namely the secreted PLA2s …

With the postgenome era rapidly approaching, new strategies for the functional analysis of
proteins are needed. To date, proteomics efforts have primarily been confined to recording …

The endocannabinoid signaling system regulates diverse physiologic processes and has
attracted considerable attention as a potential pharmaceutical target for treating diseases …

▪ Abstract Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme
that degrades the fatty acid amide family of endogenous signaling lipids, which includes the …

Chemical signals, or neurotransmitters, represent the fundamental mode for intercellular
communication in the nervous system. 1 The classical model for neurotransmitter action …

Endocannabinoids are lipid signaling molecules that regulate a wide range of mammalian
behaviors, including pain, inflammation, and cognitive/emotional state. The …

ABSTRACT A major finding—that (–)‐trans‐Δ9‐tetrahydrocannabinol (Δ9‐THC) is largely
responsible for the psychotropic effects of cannabis—prompted research in the 1970s and …

As far as can be ascertained from archeological sources, preparations of the hemp
Cannabis sativa L. were widely used by humans for either therapeutic or ritual purposes in …

N-Acyl ethanolamines (NAEs) are a large class of signaling lipids implicated in diverse
physiological processes, including nociception, cognition, anxiety, appetite, and …