New Insights into the Pathogenesis of Metabolic-Associated Fatty Liver Disease (MAFLD): Gut–Liver–Heart Crosstalk

K Yang, M Song - Nutrients, 2023 - mdpi.com
Metabolism-associated fatty liver disease (MAFLD) is a multifaceted disease that involves
complex interactions between various organs, including the gut and heart. It is defined by …

Age-related NAFLD: The use of probiotics as a supportive therapeutic intervention

LIM Campagnoli, N Marchesi, M Vairetti, A Pascale… - Cells, 2022 - mdpi.com
Human aging, a natural process characterized by structural and physiological changes,
leads to alterations of homeostatic mechanisms, decline of biological functions, and …

Rifaximin ameliorates non-alcoholic steatohepatitis in mice through regulating gut microbiome-related bile acids

J Jian, MT Nie, B Xiang, H Qian, C Yin… - Frontiers in …, 2022 - frontiersin.org
Non-alcoholic steatohepatitis (NASH) is the progressive stage of non-alcoholic fatty liver
disease (NAFLD). The non-absorbable antibiotic rifaximin has been used for treatment of …

Hepatocyte nuclear factor 4α in the pathogenesis of non-alcoholic fatty liver disease

X Pan, Y Zhang - Chinese medical journal, 2022 - journals.lww.com
Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common chronic liver
disease worldwide. It refers to a range of liver conditions affecting people who drink little or …

The gut vascular barrier: a new player in the gut–liver–brain axis

P Brescia, M Rescigno - Trends in Molecular Medicine, 2021 - cell.com
The intestinal barrier protects our body from external insults through specialized cells
organized in a multilayered structure that evolved in symbiosis with the resident microbiota …

[HTML][HTML] Glutaminolysis-ammonia-urea cycle axis, non-alcoholic fatty liver disease progression and development of novel therapies

Á Rojas, MR García-Lozano, A Gil-Gómez… - Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide,
reflecting the current epidemics of obesity, insulin resistance, type 2 diabetes mellitus, and …

Interventions for non-alcoholic liver disease: A gut microbial metabolites perspective

J Guo, CX Shi, QQ Zhang, W Deng… - Therapeutic …, 2022 - journals.sagepub.com
Over the past two decades, non-alcoholic fatty liver disease (NAFLD) has become a leading
burden of hepatocellular carcinoma and liver transplantation. Although the exact …

Microbiota–gut–brain axis: interplay between microbiota, barrier function and lymphatic system

M Zhuang, X Zhang, J Cai - Gut Microbes, 2024 - Taylor & Francis
The human gastrointestinal tract, boasting the most diverse microbial community, harbors
approximately 100 trillion microorganisms comprising viruses, bacteria, fungi, and archaea …

[HTML][HTML] Role of the afferent lymph as an immunological conduit to analyze tissue antigenic and inflammatory load

PP Nanaware, ZN Khan, CC Clement, M Shetty, I Mota… - Cell Reports, 2024 - cell.com
The lymphatic fluid is the conduit by which part of the tissue" omics" is transported to the
draining lymph node for immunosurveillance. Following cannulation of the pre-nodal …

Unveiling the role of gut dysbiosis in non-alcoholic fatty liver disease

PA Jadhav, AB Thomas, RK Nanda… - European Journal of …, 2023 - journals.lww.com
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial complicated condition, reflected
by the accumulation of extra fat in the liver. A detailed study of literature throws light on the …