Abstract Development of new drugs is of high interest for the field of cardiac and
cardiovascular diseases, which are a dominant cause of death worldwide. Before being …

The sarcoplasmatic reticulum (SR) cardiac ryanodine receptor/calcium release channel
RyR2 is an essential regulator of cardiac excitation–contraction coupling and intracellular …

Background Polymorphic ventricular tachycardia (PMVT) is a rare genetic disease
associated with structurally normal hearts which in 8% of cases can lead to sudden cardiac …

Congenital heart disease (CHD) is the most common cause of infant death associated with
birth defects. Recent next-generation genome sequencing has uncovered novel genetic …

The regulation of intracellular calcium (Ca2+) homeostasis is fundamental to maintain
normal functions in many cell types. The ryanodine receptor (RyR), the largest intracellular …

Among inherited cardiac conditions, a special place is kept by cardiomyopathies (CMPs)
and channelopathies (CNPs), which pose a substantial healthcare burden due to the …

In the heart, cardiac function is regulated by the autonomic nervous system (ANS) that
extends through the myocardium and establishes junctions at the sinus node and ventricular …

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially lethal
inherited cardiac arrhythmia condition, triggered by physical or acute emotional stress, that …

Idiopathic ventricular fibrillation (IVF) causes sudden death in young adult patients without
structural or ischemic heart disease. Most IVF cases are sporadic and some patients present …

Cardiovascular disease is a significant cause of death in humans. Various models are
necessary for the study of cardiovascular diseases, but once cellular and animal models …