Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models
K Song, X Yang, G An, X Xia, J Zhao, X Xu… - Nature …, 2022 - nature.com
Type 2 diabetes mellitus is one of the most prevalent metabolic diseases presenting with
systemic pathologies, including reproductive disorders in male diabetic patients. However …
systemic pathologies, including reproductive disorders in male diabetic patients. However …
[HTML][HTML] Deciphering the autophagy regulatory network via single-cell transcriptome analysis reveals a requirement for autophagy homeostasis in spermatogenesis
M Wang, Y Xu, Y Zhang, Y Chen, G Chang, G An… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Autophagy has been implicated as a crucial component in spermatogenesis,
and autophagy dysfunction can lead to reproductive disorders in animal models, including …
and autophagy dysfunction can lead to reproductive disorders in animal models, including …
Rare mutations in the complement regulatory gene CSMD1 are associated with male and female infertility
Infertility in men and women is a complex genetic trait with shared biological bases between
the sexes. Here, we perform a series of rare variant analyses across 73,185 women and …
the sexes. Here, we perform a series of rare variant analyses across 73,185 women and …
Efficient isolation and purification of spermatogonia, spermatocytes, and spermatids from mice, piglets, and adult boars using an optimized STA-PUT method
B Li, X Zhao, T Jin, Z Wu, H Yang - Theriogenology, 2024 - Elsevier
Spermatogenesis is a delicate and complex biological process in which spermatogonial
stem cells continue to proliferate and differentiate into mature spermatozoa, maintaining …
stem cells continue to proliferate and differentiate into mature spermatozoa, maintaining …
Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle‐yak hybrids
SX Wu, R Wan, GW Wang, YW Zhang, QE Yang - Proteomics, 2023 - Wiley Online Library
Cattle‐yak, the interspecific hybrid between yak and taurine cattle, exhibits male‐specific
sterility. Massive loss of spermatogenic cells, especially spermatocytes, results in …
sterility. Massive loss of spermatogenic cells, especially spermatocytes, results in …
Enrichment of pachytene spermatocytes and spermatids from mouse testes using standard laboratory equipment
To characterize each step of spermatogenesis, researchers must separate different
subpopulations of germ cells from testes. However, isolating discrete populations is …
subpopulations of germ cells from testes. However, isolating discrete populations is …
Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction
A Chi, C Yang, J Liu, Z Zhai, X Shi - Advanced Science, 2024 - Wiley Online Library
Therapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal
cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging …
cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging …
[HTML][HTML] Assessing testicular morphofunctionality under Roundup WG® herbicide exposure in zebrafish
L Nezzi, CE Davico, H Schramm, MS de Melo… - … Science and Pollution …, 2024 - Springer
Glyphosate-based herbicides, like Roundup WG®(RWG) used for a range of crops, such as
corn, soybean, coffee, sugarcane, rice, apple, and citrus, can reach aquatic ecosystems and …
corn, soybean, coffee, sugarcane, rice, apple, and citrus, can reach aquatic ecosystems and …
Primary culture of germ cells that portray stem cell characteristics and recipient preparation for autologous transplantation in the rhesus monkey
H Yuan, J Sun, S Wang, Z Xiang, F Yang… - Journal of Cellular …, 2022 - Wiley Online Library
Fertility preservation for prepubertal cancer patients prior to oncologic treatment is an
emerging issue, and non‐human primates are considered to constitute suitable models due …
emerging issue, and non‐human primates are considered to constitute suitable models due …
A standardized approach for multispecies purification of mammalian male germ cells by mechanical tissue dissociation and flow cytometry
Fluorescence-activated cell sorting (FACS) has been one of the methods of choice to isolate
enriched populations of mammalian testicular germ cells. Currently, it allows the …
enriched populations of mammalian testicular germ cells. Currently, it allows the …