Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …

Orexin-A and-B (also known as hypocretin-1 and-2) are neuropeptides produced in the
lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 …

The orexin peptides (orexin A, orexin B) and their receptors (orexin receptor type 1, orexin
receptor type 2) are involved in multiple physiological processes such as the regulation of …

The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …

Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic
brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the …

Human narcolepsy with cataplexy is a neurological disorder, which develops due to a
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …

Abstract Study Objectives: The orexin-producing neurons are hypothesized to be essential
for the circadian control of sleep/wake behavior, but it remains unknown whether these …

Abstract Orexin‐A (hypocretin‐1) and orexin‐B (hypocretin‐2) are hypothalamic
neuropeptides that play key roles in the regulation of wakefulness, feeding, reward …

Narcolepsy is a clinical condition characterized mainly by excessive sleepiness and
cataplexy. Hypnagogic hallucinations and sleep paralysis complete the narcoleptic tetrad; …

Orexin (hypocretin), is a neuropeptide produced by a subset of neurons in the lateral
hypothalamus. From the lateral hypothalamus, the orexin-containing neurons project their …