The neurobiological basis of narcolepsy
CE Mahoney, A Cogswell, IJ Koralnik… - Nature Reviews …, 2019 - nature.com
Narcolepsy is the most common neurological cause of chronic sleepiness. The discovery
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
about 20 years ago that narcolepsy is caused by selective loss of the neurons producing …
Orexin receptors: pharmacology and therapeutic opportunities
TE Scammell, CJ Winrow - Annual review of pharmacology and …, 2011 - annualreviews.org
Orexin-A and-B (also known as hypocretin-1 and-2) are neuropeptides produced in the
lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 …
lateral hypothalamus that promote many aspects of arousal through the OX1 and OX2 …
Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders
TR Xu, Y Yang, R Ward, L Gao, Y Liu - Cellular signalling, 2013 - Elsevier
The orexin peptides (orexin A, orexin B) and their receptors (orexin receptor type 1, orexin
receptor type 2) are involved in multiple physiological processes such as the regulation of …
receptor type 2) are involved in multiple physiological processes such as the regulation of …
Sleep disorders, obesity, and aging: the role of orexin
JP Nixon, V Mavanji, TA Butterick, CJ Billington… - Ageing research …, 2015 - Elsevier
The hypothalamic neuropeptides orexin A and B (hypocretin 1 and 2) are important
homeostatic mediators of central control of energy metabolism and maintenance of …
homeostatic mediators of central control of energy metabolism and maintenance of …
Loss of hypocretin (orexin) neurons with traumatic brain injury
CR Baumann, CL Bassetti, PO Valko… - Annals of …, 2009 - Wiley Online Library
Chronic, daytime sleepiness is a major, disabling symptom for many patients with traumatic
brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the …
brain injury (TBI), but thus far, its etiology is not well understood. Extensive loss of the …
Narcolepsy: autoimmunity, effector T cell activation due to infection, or T cell independent, major histocompatibility complex class II induced neuronal loss?
Human narcolepsy with cataplexy is a neurological disorder, which develops due to a
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …
deficiency in hypocretin producing neurons in the hypothalamus. There is a strong …
Orexin neurons are necessary for the circadian control of REM sleep
S Kantor, T Mochizuki, AM Janisiewicz, E Clark… - Sleep, 2009 - academic.oup.com
Abstract Study Objectives: The orexin-producing neurons are hypothesized to be essential
for the circadian control of sleep/wake behavior, but it remains unknown whether these …
for the circadian control of sleep/wake behavior, but it remains unknown whether these …
Role of orexin in the regulation of glucose homeostasis
H Tsuneki, T Wada, T Sasaoka - Acta physiologica, 2010 - Wiley Online Library
Abstract Orexin‐A (hypocretin‐1) and orexin‐B (hypocretin‐2) are hypothalamic
neuropeptides that play key roles in the regulation of wakefulness, feeding, reward …
neuropeptides that play key roles in the regulation of wakefulness, feeding, reward …
Autonomic disturbances in narcolepsy
G Plazzi, KK Moghadam, LS Maggi, V Donadio… - Sleep medicine …, 2011 - Elsevier
Narcolepsy is a clinical condition characterized mainly by excessive sleepiness and
cataplexy. Hypnagogic hallucinations and sleep paralysis complete the narcoleptic tetrad; …
cataplexy. Hypnagogic hallucinations and sleep paralysis complete the narcoleptic tetrad; …
An overview of the orexinergic system in different animal species
Orexin (hypocretin), is a neuropeptide produced by a subset of neurons in the lateral
hypothalamus. From the lateral hypothalamus, the orexin-containing neurons project their …
hypothalamus. From the lateral hypothalamus, the orexin-containing neurons project their …