Computer aided drug design: success and limitations

M Hassan Baig, K Ahmad, S Roy… - Current …, 2016 - ingentaconnect.com
Over the last few decades, computer-aided drug design has emerged as a powerful
technique playing a crucial role in the development of new drug molecules. Structure-based …

Modulation of neurotrophic signaling pathways by polyphenols

F Moosavi, R Hosseini, L Saso… - Drug design, development …, 2015 - Taylor & Francis
Polyphenols are an important class of phytochemicals, and several lines of evidence have
demonstrated their beneficial effects in the context of a number of pathologies including …

Flavonoids and their metabolites: prevention in cardiovascular diseases and diabetes

K Zeka, K Ruparelia, RRJ Arroo, R Budriesi, M Micucci - Diseases, 2017 - mdpi.com
The occurrence of atherosclerosis and diabetes is expanding rapidly worldwide. These two
metabolic disorders often co-occur, and are part of what is often referred to as the metabolic …

Coffee and lower risk of type 2 diabetes: arguments for a causal relationship

H Kolb, S Martin, K Kempf - Nutrients, 2021 - mdpi.com
Prospective epidemiological studies concur in an association between habitual coffee
consumption and a lower risk of type 2 diabetes. Several aspects of these studies support a …

Viral hepatitis, cholesterol metabolism, and cholesterol-lowering natural compounds

JW Liou, H Mani, JH Yen - International Journal of Molecular Sciences, 2022 - mdpi.com
Hepatitis is defined as inflammation of the liver; it can be acute or chronic. In chronic cases,
the prolonged inflammation gradually damages the liver, resulting in liver fibrosis, cirrhosis …

Polyherbal mixture ameliorates hyperglycemia, hyperlipidemia and histopathological changes of pancreas, kidney and liver in a rat model of type 1 diabetes

V Madić, A Petrović, M Jušković, D Jugović… - Journal of …, 2021 - Elsevier
Ethnopharmacological relevance One of the commonly prescribed 'anti-diabetic'polyherbal
mixtures by European herbalists is made of Rubus fruticosus and Vaccinium myrtillus …

[HTML][HTML] Potential dual inhibitors of PCSK-9 and HMG-R from natural sources in cardiovascular risk management

M Waiz, SS Alvi, MS Khan - EXCLI journal, 2022 - ncbi.nlm.nih.gov
Atherosclerotic cardiovascular disease (ASCVD) stands amongst the leading causes of
mortality worldwide and has attracted the attention of world's leading pharmaceutical …

In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea

K Saeki, S Hayakawa, S Nakano, S Ito, Y Oishi… - Molecules, 2018 - mdpi.com
Green tea has been shown to have beneficial effects on many diseases such as cancer,
obesity, inflammatory diseases, and neurodegenerative disorders. The major green tea …

Ultrasound assisted extraction of phenolic compounds from a jujube by-product with valuable bioactivities

F Berkani, ML Serralheiro, F Dahmoune, A Ressaissi… - Processes, 2020 - mdpi.com
Jujube plant is a potential source of polyphenols with biological propreties. The purpose of
this study was to investigate the application of ultrasound technique for extracting phenolic …

Antidiabetic effects of polyherbal mixture made of Centaurium erythraea, Cichorium intybus and Potentilla erecta

A Petrović, V Madić, G Stojanović, I Zlatanović… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The polyherbal mixture made of Centaurium erythraea
aerial parts and Cichorium intybus roots and Potentilla erecta rhizomes has been used for …