Dipender Gill and Stephen Burgess discuss the accompanying study by James Yarmolinsky
and colleagues investigating the associations between genetically-proxied inhibition of …

Blood pressure is regulated by a complex neurohumoral system including the renin-
angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic …

Background: Observational studies and meta-analyses have demonstrated a positive
correlation between the use of angiotensin-converting enzyme inhibitors (ACEIs) and lung …

A long-standing recognition that information from human genetics studies has the potential
to accelerate drug discovery has led to decades of research on how to leverage genetic and …

Abstract Background and Aims Antihypertensive drugs were recently reported to have an
oncogenic role in common cancer, however, whether these drugs would affect the risk of …

The process of drug development is expensive and time-consuming. In contrast, drug
repurposing can be introduced to clinical practice more quickly and at a reduced cost. Over …

Hypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases
(CVDs) including coronary artery disease, heart failure, or stroke. Despite significant …

Background: Regarding past epidemiological studies, there has been disagreement over
whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of …

Background: The causal relationship between lipid-lowering drug (LLD) use and lung
cancer risk is controversial, and the role of sphingolipid metabolism in this effect remains …

Observational studies have shown an association between liver dysfunction and
hepatocellular carcinoma (HCC), but the causality relationship between them is unclear. We …