Serving as the basis of cell life, interactions between nucleic acids and proteins play
essential roles in fundamental cellular processes. Aptamers are unique single-stranded …

Aptamers are nucleic acids that bind to a target molecule with high affinity and specificity,
which are selected from systematic evolution of ligands by exponential enrichment (SELEX) …

Quantifying interactions between biomolecules subject to various environmental conditions
is essential for applications such as drug discovery and precision medicine. This paper …

Binding of nucleic acid aptamers to specific targets and detection with fluorescence
anisotropy (FA) or fluorescence polarization (FP) take advantage of the complementary …

Biomedical applications of nucleic acid aptamers are limited by their rapid degradation in
biological fluids and generally demand tedious post-selection modifications that might …

Aptamers are synthetic single-stranded oligonucleotides (such as RNA and DNA) evolved in
vitro using Systematic Evolution of Ligands through Exponential enrichment (SELEX) …

Diagnostics that are capable of detecting multiple biomarkers are improving the accuracy
and efficiency of bioassays. In previous work we have demonstrated the potential of an …

Standard libraries for systematic evolution of ligands by exponential enrichment (SELEX)
typically utilize flanking regions that facilitate amplification of aptamers recovered from each …

Abstract Background The IgE-binding DNA aptamer 17.4 is known to inhibit the interaction of
IgE with the high-affinity IgE Fc receptor FcεRI. While this and other aptamers have been …

Aptamers are nucleic acid molecules that bind to a target molecule with high affinity and
specificity, which are generated by a process known as systematic evolution of ligands by …