Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

[HTML][HTML] Hormonal therapy in traumatic spinal cord injury

PE Ludwig, AA Patil, AJ Chamczuk… - American Journal of …, 2017 - ncbi.nlm.nih.gov
Traumatic spinal cord injuries are major health problems and the underlying
pathophysiological events and treatment strategies are currently under investigation. In this …

[HTML][HTML] Established and emerging therapies in acute spinal cord injury

R Gadot, DN Smith, M Prablek, JK Grochmal… - Neurospine, 2022 - ncbi.nlm.nih.gov
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an
annual incidence of 20–50 per million people. Following initial assessment with appropriate …

An in situ gelling drug delivery system for improved recovery after spinal cord injury

D Liu, T Jiang, W Cai, J Chen, H Zhang… - Advanced …, 2016 - Wiley Online Library
Therapeutic strategies for the spinal cord injury (SCI) are limited by the current available
drug delivery techniques. Here, an in situ gelling drug delivery system (DDS), composed of a …

Improved functional recovery in rat spinal cord injury induced by a drug combination administered with an implantable polymeric delivery system

A Bighinati, ML Focarete, C Gualandi… - Journal of …, 2020 - liebertpub.com
Spinal cord injury (SCI) is an incurable condition, in which a cascade of cellular and
molecular events triggered by inflammation and excitotoxicity impairs endogenous …

Effects of estrogen on functional and neurological recovery after spinal cord injury: An experimental study with rats

OB Letaif, AF Cristante, TEP Barros Filho, R Ferreira… - Clinics, 2015 - SciELO Brasil
OBJECTIVES: To evaluate the functional and histological effects of estrogen as a
neuroprotective agent after a standard experimentally induced spinal cord lesion …

Evaluation of the effects of hyperbaric oxygen therapy for spinal cord lesion in correlation with the moment of intervention

AF Cristante, ML Damasceno, TEP Barros Filho… - Spinal Cord, 2012 - nature.com
Study design: Experimental, controlled, animal study. Objectives: To evaluate the functional
effect of hyperbaric oxygen therapy administered shortly, one day after, and no intervention …

The effect of monosialoganglyoside (GM-1) administration in spinal cord injury

TEP Barros Filho, FF Araujo, LP Higino… - Acta ortopedica …, 2016 - SciELO Brasil
Objective: To evaluate the effect of monosialoganglioside (GM-1) in spinal cord trauma
patients seen in our service who have not been treated with methylprednisolone. Methods …

Effects of antidepressant and treadmill gait training on recovery from spinal cord injury in rats

AF Cristante, RP Oliveira, RM Marcon, R Ferreira… - Spinal Cord, 2013 - nature.com
Study design: Experimental, controlled, animal study. Objectives: To evaluate the influences
of antidepressant treatment, treadmill gait training and a combination of these therapies in …

Effect of GM1 concentration change on plasma membrane: molecular dynamics simulation and analysis

Y Lyu, S Chen, Y Zhao, H Yuan, C Zhang… - Physical Chemistry …, 2024 - pubs.rsc.org
Ganglioside GM1 is a class of glycolipids predominantly located in the nervous system.
Comprising a ceramide anchor and an oligosaccharide chain containing sialic acid, GM1 …