Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic
drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis …

Ageing is intimately connected to the induction of cell senescence,, but why this is so
remains poorly understood. A key challenge is the identification of pathways that normally …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Члены Комитета экспертов подтвердили отсутствие финансовой поддержки/конфликта
интересов. В случае сообщения о наличии конфликта интересов, член (ы) Комитета …

Background Senescent cells, which can release factors that cause inflammation and
dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …

Declining tissue nicotinamide adenine dinucleotide (NAD) levels are linked to ageing and its
associated diseases. However, the mechanism for this decline is unclear. Here, we show …

Aging and metabolism are inextricably linked, and many age-related changes in body
composition, including increased central adiposity and sarcopenia, have underpinnings in …

The COVID‐19 coronavirus is now spreading worldwide. Its pathogen, SARS‐CoV‐2, has
been shown to use angiotensin‐converting enzyme 2 (ACE2) as its host cell receptor, same …

Retrotransposable elements are deleterious at many levels, and the failure of host
surveillance systems for these elements can thus have negative consequences. However …