Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical
structures that confer them with a broad spectrum of pharmacological activities. They have …

Purpose Duloxetine (DLX) is dual serotonin and norepinephrine reuptake inhibitor suffering
from limited bioavailability (≈ 40%) due to extensive hepatic metabolism. This work aims to …

Efforts have been made to find an efficient scaffold (and its substitution) that can be used for
the treatment of lung cancer via mTOR inhibition. A detailed literature search was carried out …

Although a plethora of targeted anticancer small molecule drugs became available, the low
response rate and drug resistance imply the continuous need for expanding the anticancer …

Globally, cancer is a major cause of mortality. According to a WHO report, 20 million new
cancer cases and 9.7 million deaths were estimated due to cancer in 2022. The use of …

Tetrahydroquinoline (THQ) is an important structure for synthesizing multiple biologically
active derivatives. Thus, we developed new quinoline derivatives and investigated them as …

The focus of this review is on the synthetic routes available for different types of
pyrazoloquinoline derivatives. There are three types of synthetic methods: i) from pyrazole …

In the present work, we describe the synthesis of new tetrahydroisoquinoline derivatives and
the crystal structures of two of them. Density functional theory (DFT) investigations at the …

Lung carcinoma (LC) is responsible for almost one-third of all cancer fatalities worldwide.
Tetrahydroquinoline is an organic molecule that is the semi-hydrogenated derivative of …

Three distinctive end group-containing organotin (IV) carboxylates complexes (YDCOOSn,
CLCOOSn and BZCOOSn) were designed and synthesized. Together with theoretical …