Anxiety and depression in Alzheimer's disease: a systematic review of pathogenetic mechanisms and relation to cognitive decline

R Botto, N Callai, A Cermelli, L Causarano… - Neurological …, 2022 - Springer
Objectives To explore the pathogenetic hypothesis provided to explain the comorbidity of
anxious and depressive symptomatology and AD and to assess the association between …

Pathways connecting late-life depression and dementia

C Linnemann, UE Lang - Frontiers in pharmacology, 2020 - frontiersin.org
Late-life depression is associated with significant cognitive impairment. Meta-analyses
showed that depression is associated with an increased risk for Alzheimer's disease (AD) …

The individual course of neuropsychiatric symptoms in people with Alzheimer's and Lewy body dementia: 12-year longitudinal cohort study

AO Vik-Mo, LM Giil, MG Borda, C Ballard… - The British Journal of …, 2020 - cambridge.org
IntroductionUnderstanding the natural course of neuropsychiatric symptoms (NPS) in
dementia is important for planning patient care and trial design, but few studies have …

Revisiting apathy in Alzheimer's disease: From conceptualization to therapeutic approaches

AL Teixeira, MM Gonzales, LC De Souza… - Behavioural …, 2021 - Wiley Online Library
Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal‐
directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common …

Neuropsychiatric symptoms and activities of daily living in Alzheimer's disease: ALSOVA 5-year follow-up study

T Saari, I Hallikainen, T Hintsa… - International …, 2020 - cambridge.org
Background: Neuropsychiatric symptoms (NPSs) in Alzheimer's disease (AD) are related to
activities of daily living (ADLs), but longitudinal studies are sparse. Objectives: We …

Evaluating the clinical impact of national dementia behaviour support programs on neuropsychiatric outcomes in Australia

S Macfarlane, M Atee, T Morris, D Whiting… - Frontiers in …, 2021 - frontiersin.org
Background/Objective: People living with dementia (PLWD) in residential aged care homes
(RACHs) are frequently prescribed psychotropic medications due to the high prevalence of …

Persistent depressive symptoms are associated with frontal regional atrophy in patients with Alzheimer's disease

LI Sinclair, CG Ballard… - … Journal of Geriatric …, 2023 - Wiley Online Library
Background Depression in individuals with Alzheimer's disease (AD) is common, difficult to
treat and inadequately understood. Previous studies have identified possible differences in …

Psychometric properties of the neuropsychiatric inventory: a review

T Saari, A Koivisto, T Hintsa… - Journal of …, 2022 - content.iospress.com
Neuropsychiatric symptoms cause a significant burden to individuals with neurocognitive
disorders and their families. Insights into the clinical associations, neurobiology, and …

Neuropsychiatric symptom profiles of community‐dwelling persons living with dementia: factor structures revisited

NG Regier, NA Hodgson… - International journal of …, 2020 - Wiley Online Library
Objectives Most persons living with dementia (PLWD) will develop neuropsychiatric
symptoms (NPS) at some point. NPS are often clustered into subsyndromes with other …

Neuropsychiatric Inventory domains cluster into neuropsychiatric syndromes in Alzheimer's disease: A systematic review and meta‐analysis

SKW Hiu, T Bigirumurame, P Kunonga… - Brain and …, 2022 - Wiley Online Library
Background: Studies of patients with Alzheimer's disease (AD) have observed that
neuropsychiatric symptoms (NPS) tend to co‐occur as neuropsychiatric syndromes and …