[HTML][HTML] Multimodal functionalities of HIV-1 integrase
AN Engelman, M Kvaratskhelia - Viruses, 2022 - mdpi.com
Integrase is the retroviral protein responsible for integrating reverse transcripts into cellular
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …
genomes. Co-packaged with viral RNA and reverse transcriptase into capsid-encased viral …
[HTML][HTML] Brief Histories of Retroviral Integration Research and Associated International Conferences
DP Grandgenett, AN Engelman - Viruses, 2024 - mdpi.com
The field of retroviral integration research has a long history that started with the provirus
hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase …
hypothesis and subsequent discoveries of the retroviral reverse transcriptase and integrase …
[HTML][HTML] The HIV-1 integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding
Recent evidence indicates that the HIV-1 Integrase (IN) binds the viral genomic RNA
(gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of …
(gRNA), playing a critical role in the morphogenesis of the viral particle and in the stability of …
Emergence of compensatory mutations reveals the importance of electrostatic interactions between HIV-1 integrase and genomic RNA
ABSTRACT HIV-1 integrase (IN) has a noncatalytic function in virion maturation through its
binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding …
binding to the viral RNA genome (gRNA). Class II IN substitutions inhibit IN-gRNA binding …
[HTML][HTML] A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency
TL Hafer, A Felton, Y Delgado, H Srinivasan… - Viruses, 2023 - mdpi.com
We sought to explore the hypothesis that host factors required for HIV-1 replication also play
a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors …
a role in latency reversal. Using a CRISPR gene library of putative HIV dependency factors …
[HTML][HTML] The C-Terminal Domain of HIV-1 Integrase: A Swiss Army Knife for the Virus?
Retroviral integrase is a multimeric enzyme that catalyzes the integration of reverse-
transcribed viral DNA into the cellular genome. Beyond integration, the Human …
transcribed viral DNA into the cellular genome. Beyond integration, the Human …
Computational Modeling of IN-CTD/TAR Complex to Elucidate Additional Strategies to Inhibit HIV-1 Replication
L Qiu, S Bhutoria, GV Kalpana, X Zou - Virus-Host Interactions: Methods …, 2022 - Springer
Abstract HIV-1 integrase (IN) is a key enzyme that is essential for mediating the insertion of
retroviral DNA into the host chromosome. IN also exhibits additional functions which are not …
retroviral DNA into the host chromosome. IN also exhibits additional functions which are not …
A CRISPR Screen of HIV Dependency Factors to Identify Host Proteins Necessary for Activation of Latent HIV Proviruses
T Hafer - 2023 - search.proquest.com
The human immunodeficiency virus (HIV) integrates into host DNA and therefore persists as
a long-lived pathogen in people living with HIV (PLHIV). One of the greatest challenges to …
a long-lived pathogen in people living with HIV (PLHIV). One of the greatest challenges to …
Protein–Protein and Protein–RNA Interaction Assays to Determine Similarity of INI1/SMARCB1 and TAR RNA in Binding to HIV-1 Integrase
GV Kalpana - Virus-Host Interactions: Methods and Protocols, 2022 - Springer
INI1/SMARCB1 is a host protein that interacts with HIV-1 integrase (IN) and influences
multiple stages of viral replication. IN is a viral enzyme responsible for integration, and it also …
multiple stages of viral replication. IN is a viral enzyme responsible for integration, and it also …
Hiv-1 5'UTR RNA Structures: Connections to Infectious Lifecycle and Potential Therapeutic Applications
SA Staller - 2021 - search.proquest.com
Human immunodeficiency virus (HIV) is among the most sinister pathogens plaguing man.
As of now, we do not yet have a method to" cure" infection once the virus has integrated into …
As of now, we do not yet have a method to" cure" infection once the virus has integrated into …