The development of novel synthetic strategies to form new chemical entities in a
stereoselective manner is an ongoing significant objective in organic and medicinal …

Catalytic, stereoselective N-heterocyclic carbene-catalyzed reactions facilitate efficient
construction of many different heterocyclic compounds, such as the enantioenriched 5 …

Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …

Isatin has been widely used in drug discovery. The ring is part of many naturally occurring
compounds and is used to design compounds with diverse biological activities. These isatin …

Costunolide (COS) and dehydrocostus lactone (DEH) are two natural sesquiterpene
lactones with potential antitcancer activity against a range of cancer cell types both in vitro …

Isatin, chemically an indole-1 H-2, 3-dione, is recognised as one of the most attractive
therapeutic fragments in drug design and development. The template has turned out to be …

Spirocompounds constitute an important class of organic frameworks enveloping numerous
pharmacological activities, among them, the promising anticancer potential of …

The isatin framework is a useful template for the development of novel anticancer agents.
This is exemplified by the fact that several isatin‐based anticancer agents, such as …

The current work aims to design and synthesis a new series of isatin derivatives and greatly
enhances their cytotoxic activity. The derivatives 3-((bromophenyl) imino)-1-(morpholino …

Developing fungicides from active botanical skeletons is one of the effective methods to
tackle the resistance of plant pathogens. Based on our previous discoveries, a series of …