Soft biological tissues compromise diverse cell types and extracellular matrix constituents,
each of which can possess individual natural configurations, material properties, and rates …

Aortic dissection continues to be responsible for significant morbidity and mortality, although
recent advances in medical data assimilation and in experimental and in silico models have …

Thoracic aortopathy–aneurysm, dissection, and rupture–is increasingly responsible for
significant morbidity and mortality. Advances in medical genetics and imaging have …

Tissue growth and remodeling (G&R) is often central to disease etiology and progression, so
understanding G&R is essential for understanding disease and developing effective …

We implement full, three-dimensional constrained mixture theory for vascular growth and
remodeling into a finite element fluid–structure interaction (FSI) solver. The resulting “fluid …

Mature arteries exhibit a preferred biomechanical state in health evidenced by a narrow
range of intramural and wall shear stresses. When stresses are perturbed by changes in …

Physics-based computational models of the cardiovascular system are increasingly used to
simulate hemodynamics, tissue mechanics, and physiology in evolving healthy and …

Tissues grow and remodel in response to mechanical cues, extracellular and intracellular
signals experienced through various biological events, from the developing embryo to …

Multiscale computational modeling aims to connect the complex networks of effects at
different length and/or time scales. For example, these networks often include intracellular …

Blood vessels are subjected to complex biomechanical loads, primarily from pressure-driven
blood flow. Abnormal loading associated with vascular grafts, arising from altered …