Apoptosis is a form of programmed and controlled cell death that accounts for the majority of
cellular death in bioprocesses. Cell death affects culture longevity and product quality; it is …

With the rising application of systems biology, sensitivity analysis methods have been widely
applied to study the biological systems, including metabolic networks, signalling pathways …

A systems pharmacology model typically integrates pharmacokinetic, biochemical network,
and systems biology concepts into a unifying approach. It typically consists of a large …

Recent studies have revealed that multiple intracellular signaling proteins may assemble
into structured, yet sometimes infinite, higher-order signaling machines for transmission of …

The goal of this review article is to assess how relevant is the concept of dissipative structure
for understanding the dynamical bases of non-equilibrium self-organization in biological …

Abstract CD95 (APO-1/Fas) is a member of the death receptor (DR) family. Stimulation of
CD95 leads to induction of apoptotic and non-apoptotic signaling pathways. The formation …

During the course of an immune response, antigen-reactive T cells clonally expand and then
are removed by apoptosis to maintain immune homeostasis. Life and death of T cells is …

Physicochemical modelling of signal transduction links fundamental chemical and physical
principles, prior knowledge about regulatory pathways, and experimental data of various …

Mathematical equations are fundamental to modeling biological networks, but as networks
get large and revisions frequent, it becomes difficult to manage equations directly or to …

The p53 tumor suppressor responds to certain cellular stresses by inducing transcriptional
programs that can lead to growth arrest or apoptosis. However, the molecular mechanisms …