In the past 20 years we have learned a great deal about GABA A receptor (GABA AR)
subtypes, and which behaviors are regulated or which drug effects are mediated by each …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

BACKGROUND: This study aims to estimate general and racial-ethnic specific cumulative
probability of developing dependence among nicotine, alcohol, cannabis or cocaine users …

Although it is evident from the literature that altered GABA B receptor function does affect
behavior, these results often do not correspond well. These differences could be due to the …

Despite the declining overall rate of cigarette smoking in the general population in the
United States, the prevalence of smoking is estimated to be as high as 80% among …

GABAA receptors form the major class of inhibitory neurotransmitter receptors in the
mammalian brain. This review sets out to summarize the evidence that variations in genes …

Drug‐related phenotypes are common complex and highly heritable traits. In the last few
years, candidate gene (CGAS) and genome‐wide association studies (GWAS) have …

GABAA receptors have important physiological functions, as revealed by pharmacological
studies and experiments involving gene-targeted mouse models, and are the target of …

The modulation of neuronal cell firing is mediated by the release of the neurotransmitter
GABA (γ-aminobuytric acid), which binds to two major families of receptors. The ionotropic …

The functional interplay between the corticolimbic GABAergic and opioidergic systems plays
a crucial role in regulating the reward system and cognitive aspects of motivational …